产品货号：
Z38041
中文名称：
FHIT抗体
英文名称：
Anti-FHIT Antibody (Clone#1093CT23.1.2)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FHIT Antibody (Clone#1093CT23.1.2) |
| 指标别名 | Fragile histidine triad diadenosine triphosphatase;AP3Aase;FRA3B;FHIT |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM |
| 基因名称 | FHIT |
| 克隆号 | 1093CT23.1.2 |
| 抗体来源 | Mouse |
| 免疫原 | This FHIT antibody is generated from a mouse immunized with a recombinant protein. |
| 计算分子量 | 17kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Cleaves P (1)-P (3)-bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP.Can also hydrolyze P (1)-P (4)-bis (5'- adenosyl) tetraphosphate (Ap4A),but has extremely low activity with ATP.Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival,such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways.Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis.Induction of apoptosis depends on the ability of FHIT to bind P (1)-P (3)-bis (5'-adenosyl) triphosphate or related compounds,but does not require its catalytic activity,it may in part come from the mitochondrial form,which sensitizes the low- affinity Ca (2+) transporters,enhancing mitochondrial calcium uptake.Functions as tumor suppressor. |
| Uniprot ID | P49789 |
相关搜索：FHIT抗体，FHIT单抗，Anti-FHIT Antibody (Clone#1093CT23.1.2)